QQ.1.. Discuss biotransformation of toxicants in our body and excretion of toxicants.
- Biotransformation converts lipophilic toxicants to water-soluble metabolites for excretion.
- Phase I reactions introduce polar groups, often by CYP enzymes, sometimes causing bioactivation.
- Phase II reactions conjugate metabolites with polar molecules (e.g., glucuronic acid, glutathione).
- Excretion removes toxicants primarily via urinary (renal) and fecal (biliary) routes.
Answer: The human body possesses sophisticated mechanisms to handle exposure to toxicants, broadly categorized as biotransformation and excretion. These processes aim to convert foreign chemical compounds (xenobiotics) into more water-soluble forms, facilitating their elimination and reducing their potential for harm. This defense system is crucial for maintaining physiological homeostasis. Biotransformation, also known as metabolism, primarily occurs in the liver, but also in other organs like the kid...