Q1. Answer the following questions within 750 words.

• 1.) An elderly lady of 65 years was well up until 8 AM on the day of admission. She has been a diabetic and a hypertensive for the past 8 years. She is on oral hypoglycemics and anti-hypertensives. On admission at 10 AM she was conscious, opened eyes spontaneously but was aphasic and had no auditory comprehension. She has right hemiplegia grade 0. Her CT head scan shows no parenchymal abnormalities but a hyperdense MCA on the left. Discuss further management. What further workup is necessary before thrombolysis, contraindications, precautions, and management of thrombolysis in acute ischemic stroke. (750 words)
• 2.) A 60-year-old diabetic patient with chronic kidney disease, and treatment with corticosteroids for nephrotic syndrome presented with fever, disorientation and was in a fugue state with naming difficulties and aphasia. A computed tomographic scan was negative for brain injury. Cerebrospinal fluid (CSF) tests were positive: the fluid was turbid, glycorrhachia was 140 mg/dl (normal range, 50–80 mg/dl), proteinorrachia was normal, and the CSF white cell count was 132 (normal range, 0–5). The patient was given broad-spectrum antibiotic therapy while awaiting the CSF culture results. The CSF culture was negative for bacteria. Magnetic resonance imaging detected diffuse signal changes in the cortical and subcortical matter, especially in the frontal-temporal region and the parietal region in both cerebral hemispheres, but particularly in the left hemisphere. The EEG showed a bilateral slowing with disappearance of the normal waveforms and occasional high-voltage spike-and-wave discharges. What is your diagnosis? How will you manage? (750 words)