Q1. Explain Trisomy 21 (Down's Syndrome) and Trisomy 18 (Edward's Syndrome) in detail.
- Trisomy is aneuploidy (2n+1) caused by an extra chromosome, usually from non-disjunction during meiosis.
- Trisomy 21 (Down's Syndrome) is an extra chromosome 21, causing intellectual disability and distinct physical traits.
- Down's Syndrome incidence rises with maternal age, primarily due to non-disjunction in maternal meiosis I.
- Trisomy 18 (Edward's Syndrome) is an extra chromosome 18, leading to severe developmental abnormalities.
Answer: Aneuploidy refers to a condition where an individual possesses an abnormal number of chromosomes, deviating from the normal diploid set. Trisomy is a specific type of aneuploidy characterized by the presence of an extra copy of a particular chromosome in an otherwise diploid cell, resulting in a total of (2n+1) chromosomes. This typically arises from non-disjunction, an error during meiosis where homologous chromosomes or sister chromatids fail to separate properly, leading to gametes with an im...